Pathway analysis on 576 genes prioritized by MAGeCK (top 1% of multiple screening replicates combining the acute and chronic screens) revealed pathways were significantly enriched (FDR < 0.05) within these top candidates, including many that have been previously shown to be important for tumor immune evasion, such as lipopolysaccharide response, extrinsic apoptosis signaling, NF-κB activation, JAK-STAT signaling, antigen presentation, and Wnt signaling10–14,20 (Fig. 1c and Supplementary Data 4). Here, SOAT1 is linked to neoplasm.