LRRK2 and Parkinson disease: All lines underwent thorough genetic quality control and exclusion criteria–based profiling, which yielded lines from 45 healthy controls, 32 sporadic PD, 8 GBA PD and 6 LRRK2 PD donors; 5 participants also donated a second skin biopsy 3 to 6 years later, which were analyzed as independent lines, for a total of 96 cell lines (Methods, Supplementary Data 1).