Taking the conventional flow cytometry and Tocky data together, we reasoned that the highly activated Treg, even though reduced in number after dual HSV/BRAFi therapy, were having a functionally important role in limiting the activity of the antigen-experienced conventional CD4+, which contributed to the slowing of tumor growth (figure 4), and that depleting these remaining Treg would further enhance therapy. Here, CD4 is linked to neoplasm.