In recent years, more studies have demonstrated that circulating lncRNAs, such as HOX transcript antisense RNAs (HOTAIR), colon cancer-associated transcripts (CCAT), metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), hepatocellular carcinoma upregulated lncRNA (HULC), HOXA transcript at the distal tip (HOTTIP) and H19, have been confirmed to be associated with CRC development, invasion and metastasis and present as noninvasive molecular markers [165–167]. The gene discussed is MALAT1; the disease is hepatocellular carcinoma.