NRG1 and schizophrenia: Most importantly, an increasing number of studies have reported that the NRG1-ErbB4 signaling pathway is related to glutamatergic, GABAergic and dopaminergic neurotransmission [8]; this signaling pathway also plays a vital role in the psychopathological mechanism of schizophrenia, and may be useful in evaluating the effect of antipsychotic medication therapies or new drug developments [9].