NRG1 and schizophrenia: In particular, one previous study found that NRG1 (both endogenous and exogenous) plays an important role in maintaining evoked GABA release in the rat prefrontal cortex (GABAergic dysfunction is implicated in schizophrenia), suggesting that NRG1 may be involved in interactions with other signaling pathways which could be useful in understanding the pathogenesis of schizophrenia and the effects of treatment [28].