NRG1 and schizophrenia: In addition, an imaging genetic study suggested that the risk T allele of SNP8NRG243177, which has been identified as a functional single-nucleotide polymorphism (SNP) in a regulatory domain of NRG1 that impacts NRG1 function, can contribute to the enlargement of the lateral ventricles observed in early phases of schizophrenia [14].