In contrast, Parlapani et al. found that the expression of NRG1 type I is decreased and isoform II is increased in the prefrontal cortex of elderly patients with schizophrenia, indicating that the altered expression of NRG1 may play an important role during neurodevelopment, neuronal migration and differentiation in schizophrenia [13]. The gene discussed is NRG1; the disease is schizophrenia.