Lenvatinib was preferred for patients ≤ 60 years of age, AFP > 200 ng/mL, tumor size > 5 cm, without portal vein thrombosis, with previous anti-HCC treatment for TTP, and was preferred for patients ≤ 60 years of age and AFP > 200 ng/mL for PFS. The gene discussed is AFP; the disease is neoplasm.