Moreover, some herbal medicines have shown an inhibitory effect on STAT3 and offered protection against liver fibrosis induced by CCl4, for instance; cucurbitacin-B from many plants of the family Cucurtitaceae [44]; asiatic acid extracted from Centella asiatica [45]; S-allyl-cysteine (SAC) from aged garlic extract [46]; and “CCM111” extracted from Antrodia cinnamomea [47]. This evidence concerns the gene STAT3 and Hepatic fibrosis.