In our study, we characterized the presence of EVs derived from red blood cells (CD235a+), total leucocytes (CD45+), LEC (CD45− podoplanin+), blood endothelial cells (CD45− CD62e+) and platelets (CD45−, C-type lectin-like type II + (CLEC2+)) in the plasma of COVID-19 convalescent donors (Figure 5A–G). Here, PDPN is linked to COVID-19.