The expression levels of six pro-apoptotic genes (COX-2, caspase-3, P450, iNOS, Bcl-2, and BAX) of the CIP–MSN-treated and control groups at different time points (7 and 14 dpi) were investigated by qRT-PCR (Figure 5A,B). Here, BAX is linked to hereditary sensory and autonomic neuropathy.