In this approach, targeted cells that are usually investigated in cancer nano-therapy include the endothelial cells of tumors [12], and more specifically receptors such as vascular endothelial growth factor (VEGFR), integrins (α4β3, α5β1), vascular cell adhesion molecule-1 (VCAM-1) and matrix metalloproteinase (MMPs). Here, VCAM1 is linked to cancer.