Our results revealed an increase in the serum CEA level in EAC-bearing mice, which were similar to the findings of Hashem et al. [17] and Abd Eldaim et al. [19], who reported an elevation in the serum level of CEA in EAC-bearing mice, indicating the tumor metastasis in different organs, comprising ovarian, pancreatic, gastric, and colorectal tumors [20]. Here, CEACAM5 is linked to colorectal neoplasm.