We discovered that this model was suitable for inducing neuroinflammation [23,24,25], which is particularly related to the similar pathophysiological state of AD [26,27], and YJT significantly reduced microglial activation-mediated neuronal cell damage in hippocampal areas, particularly by regulating Sirtuin 6 (Sirt6) protein levels in the hippocampus. Here, SIRT6 is linked to Alzheimer disease.