FOLH1 and neoplasm: Comparing our lead compound to former generations of PSMA-targeting hybrid molecules, we concluded that a PSMA-11-based core structure tolerated dye conjugation better than its PSMA-617-based counterpart, as the HBED compounds [68Ga]Ga-Glu-urea-Lys-HBED-CC-IRDye800CW and [68Ga]Ga-Glu-urea-Lys-(HE)3-HBED-CC-IRDye800CW exhibited significantly higher tumor enhancement after dye conjugation [11,12].