A number of proteins downregulated 48 h after infection were similar between LASV and MOPV (UBE2E3, PLSCR3) or specifically modulated during MOPV infection, such as an RNA-binding protein (FRX2), a mediator involved in RNA metabolism (SREK1), a proteasome-interacting molecule (PITHD1) [83], TMEM109, a subunit of the RNA exosome complex (EXOSC7), and a deubiquitinase (USP13). The gene discussed is USP13; the disease is infection.