CYCS and COVID-19: Diverse viroporins from RNA viruses, such as the E protein from COVID-19 (CoV), p7 from the hepatitis C virus (HCV), and the 2B, 3A, and NS4A proteins from the poliovirus (PV) trigger apoptosis through the intrinsic pathway which is partially located in the mitochondria and it induces C cytochrome relocation to the cell cytoplasm [35], while other viroporins, such as US21 from the human cytomegalovirus (CMV) and 2B from the coxsackievirus (CaV) reduce cell susceptibility to apoptosis through a calcium homeostasis alteration [36,37].