Importantly, in subsequent infections that utilized αvβ6-expressing BHK-21 cell types and non-cell culture-adapted virus, yields of O FMDV were more comparable to those of A/SAT1/SAT2; indeed, titres of >107 PFU/mL were consistently obtained, highlighting the role of αvβ6 as a key integrin for this serotype. The gene discussed is SAT2; the disease is infection.