To further investigate if the difference in immunity observed in AdIiPA-vaccinated BALB/c and C57BL/6 mice was dependent on the difference in the general genetic background of the two mouse strains or in the involved MHC restriction elements, we compared the ability to control virus infection between BALB/c mice, C57BL mice, and B10.D2 mice (Figure 3C). The gene discussed is HLA-C; the disease is viral infectious disease.