Patients with acute HFRS presented with fever and high levels of HGB, CRP, suPAR, CXCL9, CXCL10, TGF-β3, TNF-α, and HTNV loads but low levels of PLT, BUN, and UO (Figure 1 and Figure 2). The gene discussed is CYGB; the disease is hemorrhagic fever with renal syndrome.