GPT and Hepatic fibrosis: These include plasma HBV-DNA (which reflects viral proliferation), the viral secreted antigens HBsAg (an embedded viral protein that is related to the viral envelope) and HBeAg (a pre-core protein), liver enzymes (alanine aminotransferase, ALT, and aspartate transaminase, AST, which are elevated in chronic HBV hepatitis patients), in combination with a non-invasive assessment of liver fibrosis [4].