Indeed, an ankyrin repeat protein designated V-1 has been suggested to act as a possible coordinate regulator of the expression of TH, DDC, DBH and PNMT mRNAs [75]; moreover, consistently with the downregulation of VMAT2 expression, we observed a suppression of dopamine uptake from the cell culture medium upon viral infection. The gene discussed is PNMT; the disease is viral infectious disease.