In addition to these conventionally studied CD4 and CD8 T-cell subsets, recently identified innate-like T-cells such as the gamma delta T-cell (γδT), mucosal-associated invariant T-cells (MAIT), and natural killer T-cells (NKT) are enriched in mucosal tissues and have been reported to provide protective effector activities against human intestinal infections. This evidence concerns the gene CD8A and digestive system infectious disorder.