In addition to these conventionally studied CD4 and CD8 T-cell subsets, recently identified innate-like T-cells such as the gamma delta T-cell (γδT), mucosal-associated invariant T-cells (MAIT), and natural killer T-cells (NKT) are enriched in mucosal tissues and have been reported to provide protective effector activities against human intestinal infections. The gene discussed is CD4; the disease is digestive system infectious disorder.