In the review of 40 cases of atypical DPN by Magro et al., FISH targeting 6p25 (RREB1), 6q23 (MYB), 11q13 (CCND1), and Cep6 performed in 10 of the 40 cases showed cytogenetic abnormalities characteristic of melanoma in three cases despite borderline histomorphologic features [8]. Here, RREB1 is linked to melanoma.