According to Lijnen et al., inhibition of VPAC1 receptors by monoclonal antibodies in WT mice, fed a high-fat diet to induce obesity for 15 weeks, failed to modify weight gain and fat mass, but induced adipocyte hypertrophy in the subcutaneous compartment [35]. The gene discussed is VIPR1; the disease is obesity due to melanocortin 4 receptor deficiency.