Another range of issues results from the fact that the increase in cTns levels takes place in the case of myocardial necrosis of any etiology, and sometimes in the absence of irreversible myocardial injury (for instance, in case of reversible injury induced by physical exercises, renal failure, or the influence of false-positive factors) [21,22,23,24,25,26,27,28]. The gene discussed is CTNS; the disease is Renal insufficiency.