On the other hand, HMGB1 is normally detected at low levels in the plasma of untreated patients with cancer [36] or is overexpressed in some tumors [37]; therefore, the changes in HMGB1 levels in plasma of human patients should also be investigated to further validate the significance of changes in HMGB1 levels as a therapeutic biomarker for BNCT. The gene discussed is HMGB1; the disease is cancer.