This was validated in E-selectin-expressing endothelial cells, in which IKK complex assembly was inhibited in vitro and in vivo, resulting in the reduction of NF-κB activity specifically in E-selectin-expressing cells as well as the attenuation of experimental arthritis (STIA and AIA) in mice [230,299]. This evidence concerns the gene NFKB1 and arthritic joint disease.