With respect to the interplay between tumor cells and MΦ, there is evidence that triple negative breast cancer cells secrete elevated levels of plasminogen activator inhibitor 1 (PAI-1) and interleukin 10 (IL10) after the restoration of miR-200c levels, thereby supporting a tumor-promoting M2-like phenotype in TAM [34]. Here, SERPINE1 is linked to neoplasm.