Furthermore, 2 exerted antiproliferative and proapoptotic effects in eight human (A2058, SK-MEL-28, HCT-8, LS160, SiHa, HL-60, SK-BR-3) and one murine (B16F10-Nex2) tumor cell lines in vitro by downregulating Akt and activating p38 MAPK signaling pathways through the generation of reactive oxygen species (ROS). This evidence concerns the gene AKT1 and neoplasm.