The observed anti-AChE in fraction 7 containing these compounds beside the recent reports describing the anti-AChE of these compounds analogues together pushed us to confirm their inhibitory effect via molecular docking; including two well-known AChE inhibitory molecules namely, 2-((1-Benzylpiperidin-4-yl) methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one (donepezil, FDA approved drug for AD treatment) and dihydrotanshinone I (DHI) were employed. The gene discussed is ACHE; the disease is Alzheimer disease.