Moreover, NLRP3 activation can lead to pyroptosis, an inflammatory programmed cell death pathway activated through Gasdermin D (GSDMD) cleavage by caspase 1, 4, 5, and/or 11 (Figure 4) that takes place in T lymphocytes and is crucial in the pathogenetic process associated to viral infections [51]. This evidence concerns the gene GSDMD and viral infectious disease.