IFNA1 and COVID-19: Regarding the pathways driving IFN responses to SARS-CoV-2 infection, it is well known that the virus is a poor type I IFN inducer in vitro [55] and IFN-I analysis on a cohort of 50 COVID-19 patients with various disease severity revealed a highly impaired IFN-I response (characterized by no IFN-β and low IFN-α production and activity), which was associated with a persistent viremia and an exacerbated inflammatory state [56].