Once activated, NLRP3 inflammasome causes the release of several proinflammatory cytokines, including IL-6 and IL-1β (Figure 4) [48], which have been reported to have a key role in the pathogenesis of acute lung injury, included COVID-19, affecting type II alveolar epithelial cells ACE2 expression [49,50]. This evidence concerns the gene NLRP3 and COVID-19.