In severe manifestations of COVID-19, a massive inflammatory response appears to occur through stimulation of the pyrin domain-containing 3 (NLRP3) inflammasome, that consists in the sensor NLRP3, a NOD-like receptor that interacts with the N-terminus of the adapter protein ASC (also known as PYCARD) via PYD–PYD interactions and an the effector caspase 1, recruited by the caspase recruitment domain (CARD) present in the C-terminus of ASC [45]. This evidence concerns the gene NLRP3 and COVID-19.