Similar to downregulation of CaMKII in HBV replicating cell (Figure 1, Figure 3, Figure 4C,D, Figure 6, Figure 7, Figure 8 and Figure 11), we suggest that suppressed AMPK in HBV replicating cell (Figure 3, Figure 4C,D, Figure 5C,D, Figure 6, Figure 7, Figure 8 and Figure 11) could enhance HCC progression, whereas overexpression of either CaMKII (Figure 4C,D, Figure 6, Figure S6, Figure 7B and Figure S7B) and AMPK (Figure 5C,D, Figure 8 and Figure S7C,D) could inhibit the AKT/mTOR signaling pathway in an HBx-independent manner (Figure 11). Here, CAMK2G is linked to hepatocellular carcinoma.