FOLH1 and prostate neoplasm: We have recently demonstrated that non-targeted generation-4 hydroxy terminated PAMAM dendrimers with size around 5 nm below renal filtration cut-off quickly cleared from bloodstream with major accumulation in kidneys, followed by liver and very low (below 1% ID/g) uptake in PSMA+ PC3 PIP and PSMA− PC3 flu prostate tumor models [35].