Specifically, the cells chosen were the BrafV600E, Pten−/−, and Cdkn2a−/− male melanoma mouse line, YUMM 1.7, and the UV-irradiated YUMMER 1.7 with a higher mutational burden than YUMM 1.7, along with the human melanoma SK-MEL−28 cell line. The gene discussed is CDKN2A; the disease is melanoma.