Thus, the aim of this prospective observational cohort pilot study [24] was to investigate the association between IL-6 rs1800795, IL-6 rs1800796, IL-6 rs1800797, IL-8 rs4073, TNFα rs1800629 SNPs, and response to opioid therapy, both in terms of efficacy and safety, in a cohort of pediatric cancer patients. Here, TNF is linked to cancer.