TGFB1 and non-small cell lung carcinoma: Additionally, Withaferin A has demonstrated potent activity against TNF-α-induced epithelial–mesenchymal transition (EMT) and TGF-β in A549 and H1299 non-small cell lung cancer (NSCLC) cell lines and has also induced apoptosis and cell cycle arrest by inhibiting the PI3K/Akt pathway [109,110].