Recent reports have shown the ability of WS root extracts to suppress lipogenesis in 22Rv1 cells, most likely by decreasing the expression levels of p-Akt and c-Myc, and this possibly indicates the mechanism of fatty acid metabolism in malignant cells and a novel strategy of inducing antitumor activity in prostate cancer [101].Kunimasa et al. [128] found that Withaferin A combined with glucose metabolism focused therapy might be an effective treatment for cancer cells resistant to tyrosine kinase inhibitors (TKI). Here, AKT1 is linked to cancer.