Currently, native L-ASNase from Escherichia coli (EcA) or Dickeya dadantii (formerly known as Erwinia chrysanthemi) (ErA), along with the pegylated form of E. coli asparaginase, are successfully used for the treatment of patients with acute lymphoblastic leukemia [3,4,5,6]. The gene discussed is ASPG; the disease is acute lymphoblastic leukemia.