In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mouse model of Parkinson’s disease, CS-NLCs (IN) and TAT-CS-NLCs (IN) improved motor recovery and increased numbers of tyrosine hydroxylase fibers in striatum and tyrosine hydroxylase neuron levels in substantia nigra more than GDNF solution (IN). Here, TH is linked to Parkinson disease.