Besides the possible association between CRP and clearance, the pharmacokinetics parameters (CL = 51.7 L/h, V = 1490 L) of our study are similar to the results of previously published haloperidol models (CL range from 42.4 L/h to 88 L/h, V range from 2060 L to 3169 L) in a healthy population and studies on schizophrenia [29,43]. This evidence concerns the gene CRP and schizophrenia.