TNF and Arthritis: Therapeutic strategies employing non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids (GCs), disease modifying anti-rheumatic drugs (DMARDs), immunotherapeutic agents (i.e., antisense oligonucleotides (ASOs), cytokine inhibitors such as TNF-α inhibitors and nuclear factor-κB inhibitors etc.), and cells have been investigated to relieve pain and control inflammation in arthritis.