While the role of inflammation and oxidative stress (OS) in HTN is currently extensively explored [7,8,9,10], the precise deleterious effect of HTN on endothelial integrity and the involvement of molecules such as the nuclear factor erythroid 2-related factor 2 (Nrf2) in the pathogenesis and evolution of raised BP remain elusive [11,12]. Here, NFE2L2 is linked to hypertensive disorder.