Recent studies have demonstrated the positive effect of the intra-articular injection of therapeutic agents such as corticosteroid [27], hyaluronic acid [28], tumor necrosis factor antagonist (infliximab) [29], mesenchymal stem cell (MSC) [30], and platelet-rich plasma (PRP) [31] in reducing cartilage destruction, joint swelling, and inflammation in RA patients. Here, TNF is linked to rheumatoid arthritis.