PRKCE and pachyonychia congenita: Various studies have described various mechanisms by which PKCε is involved in the progression and metastasis of PC, including enhancing aerobic glycolysis [132], the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)) [131], phosphorylation of Vimentin [133], and interaction with BCL2 associated x, apoptosis regulator (Bax) [134].