An in-depth in vitro migration study on Panc1 pancreatic cancer cells to clarify the role of PKD in cancer cell migration indicated that the absence of each PKD isoform exerts a considerable effect on cell speed and migration persistence, and that the absence of PKD1 is associated with a significant increase in Panc1 cell deformability [140]. The gene discussed is PRKD1; the disease is familial pancreatic carcinoma.