MAPK4 and pachyonychia congenita: In addition, although the role of many kinases in PC progression has been reported, such as EGFR [70], EphA2 [71,72], Janus kinase 1 (JAK1) [73], JAK2 [74], c-Jun N-terminal kinase (JNK) [15], MAPK4 [75], protein tyrosine kinase 6 (PTK6) [76], ribosomal S6 kinases (RSKs) [77], vascular endothelial growth factor receptor 3 (VEGFR-3) [78], etc., only a few of them have been cited as examples, and the mechanism of their effect on PC progression is discussed in detail.