In PCa cells, NF-κB inflammatory signaling is constitutively activated to facilitate PCa cell AI growth and survival by up-regulating the expression of survival genes, such as cytokines (CXCL13, the receptor activator of nuclear factor-kappaB ligand (RANKL), etc.)and stem cell transcription factors (TWIST2, SOX2, OCT4 and NANOG, etc.). This evidence concerns the gene POU5F1 and posterior cortical atrophy.