Treatment with apigenin leads to down-regulation of NF-κB-regulating genes, such as Bcl-2, cyclooxygenase-2 (COX-2) and matrix metalloproteinase 9 (MMP-9), and sensitizes hormone-refractory PCa cells to TNFα-induced apoptosis [33]. The gene discussed is BCL2; the disease is posterior cortical atrophy.