F9 and hemophilia: Micro/nanobubble-assisted ultrasound has been demonstrated in a number of new therapeutic areas, such as combination with insulin-like growth factor-1 to generate a better therapeutic response to noise-induced hearing loss [129] or association with transportation of corresponding genes or transposase to the liver of hemophilia B mice to enhance the expression level of factor IX in the liver, so as to achieve the purpose of adjuvant treatment of hemophilia [130].