In this study, we aimed to determine the expression of miR-512-3p- and miR-515-5p-regulated genes, specifically hGCM-1 and c-FLIP, as well as the expression of the main trophoblast differentiation marker hCG during ex vivo infection of HPE, and examined how inhibition or overexpression of both miRNAs affects parasite infection. The gene discussed is CFLAR; the disease is infection.