Yao et al. also report in patients experiencing severe disease, higher circulating levels of IL-6, as well as TNF-α and CXCL10 (C-X-C motif chemokine ligand 10), which remain high for weeks during the infection and this inability to achieve normal concentration for a long period result to decreased ability to terminate the infection [95]. This evidence concerns the gene CXCL10 and infection.