RELA and infection: Downregulation and impaired activation of NF-κB-p65 and NF-κB-p50/105 in mouse macrophages during the course of infection contributes to macrophage polarization towards M2 and Mreg phenotypes and downregulation of proinflammatory IL-12 release and increased secretion of Th2/Threg cytokines: IL-4 and IL-10, respectively [126].