HMGB1 and schistosomiasis: Therefore, based on the extensive body of literature, the present review briefly summarizes the structure and functions of HMGB1, the development and migration of schistosomes in the host, factors that contribute to the regulation of schistosome-induced liver disease, the crucial role of HMGB1 in schistosome-induced liver disease, and HMGB1 as a potential target for treatment of schistosomiasis-associated inflammation and fibrosis.