HMGB1 and necrotizing enterocolitis: For example, Lian et al. [87] reported that upon release, HMGB1 acted as a late-phase mediator of lipopolysaccharide-induced depression, which could be abrogated by a TLR4 inhibitor, while Yu et al. [88] found out that the application of glycyrrhizin (GL), a natural antagonist of HMGB1 extracted from licorice root, inhibited activation of the TLR4/NF-κB signaling pathway in necrotizing enterocolitis.