An interesting recent study reported that inhibition of HMGB1/TLR4 intracellular signaling decreased production of NF-κB, TNF-α, and IL-6 in cholestatic liver inflammation, which further confirms the close interactions among HMGB1, TLR4, and NF-κB in the promotion of liver inflammation [95]. The gene discussed is IL6; the disease is Hepatitis.