They found that sarsasapogenin inhibited key enzymes involved in Alzheimer’s disease pathogenesis, including acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), beta-secretase 1 precursor (BACE1), and monoaminoxidase-B (MAO-B) in a concentration-dependent way [32]. Here, BACE1 is linked to early-onset autosomal dominant Alzheimer disease.