Likewise, since macerated fruit was also the most potent inhibitor against the enzymes AChE, BChE, tyrosinase, elastase and α-amylase, this plant part can be a novel formulation consisting of a combined therapeutic effect to manage diabetes together with its related complications by improving cognitive performance and ameliorating cutaneous manifestations particularly diabetic dermopathy, xerosis and acanthosis nigricans. Here, ACHE is linked to acanthosis nigricans.