TYR and acanthosis nigricans: Likewise, since macerated fruit was also the most potent inhibitor against the enzymes AChE, BChE, tyrosinase, elastase and α-amylase, this plant part can be a novel formulation consisting of a combined therapeutic effect to manage diabetes together with its related complications by improving cognitive performance and ameliorating cutaneous manifestations particularly diabetic dermopathy, xerosis and acanthosis nigricans.